Differential accumulation of diacyl and plasmalogenic diglycerides during myocardial ischemia.

Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart

Degradation of phospholipid molecular species during experimental cerebral ischemia in rats.

Previous investigators have shown that free fatty acids that accumulate during ischemia are an indicator of evolution in ischemic brain damage. Our study describes the temporal relations between free fatty acid accumulation and degradation of phospholipid molecular species after cerebral ischemia. Using the four-vessel occlusion model of adult Wistar rats, we analyzed quantitatively the cerebra...

Metabolism of Glycerolipids

Phosphatidylethanolamine or phosphatidylcholine may be synthesized in mammalian tissues from diglycerides and cytidine diphosphate ethanolamine or cytidine diphosphate choline, respectively (1). Hydrolysis of the naturally occurring phosphatides has indicated that often the fatty acids at the @ position are unsaturated whereas those at (Y’ are more often saturated (2-4). Although it is possible...

Effect of losartan on NOX2 transcription following acute myocardial ischemia-reperfusion

Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...

Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia

BACKGROUND AND PURPOSE The initial steps in the cascade leading to cell death are still unknown because of the limitations of the existing methodology, strategy, and modalities used. METHODS Imaging mass spectrometry (IMS) was used to measure dynamic molecular changes of phosphatidylcholine (PC) species in the rat hippocampus after transient global ischemia (TGI) for 6min. Fresh frozen sectio...